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目的了解新生儿血源乙型肝炎(乙肝)疫苗(HepB)接种的长期免疫效果和加强免疫的必要性。方法对黄浦区1986年出生并全程接种血源HepB的对象隔年随访,采血检测和分析乙肝表面抗原(HBs Ag)携带率、乙肝表面抗体(Anti-HBs)阳性率、乙肝核心抗体(Anti-HBc)阳性率。结果在28年14次随访的213~988例样本中,HBsAg携带率在0.19%~0.98%之间,未随免疫时间延长出现上升趋势(χ~2=0.870,P=0.351);Anti-HBc阳性率在0.96%~3.40%之间,随免疫时间延长未呈现下降趋势(χ~2=3.457,P=0.063);Anti-HBs阳性率在20.11%~89.72%之间,随免疫时间延长呈现下降趋势(χ~2=797.206,P<0.001)。结论新生儿使用血源Hep B免疫有较好的持久性,免疫后28年无需加强免疫。
Objective To understand the long-term immunization effect and the necessity of boosting immunity in newborn blood-borne hepatitis B (HepB) vaccination. Methods The follow-up of the subjects who were born Hepatitis B virus from Hepu in Hepatitis B District of Huangpu District in 1986 were enrolled in this study. Blood samples were collected to detect and analyze the carrier rate of HBsAg, the positive rate of Anti-HBs and the level of Anti-HBc ) Positive rate. Results In 213 ~ 988 samples of 14 follow-up visits in 28 years, the carrier rate of HBsAg was between 0.19% and 0.98%, but did not increase with the increase of immunization time (χ ~ 2 = 0.870, P = 0.351) The positive rate of Anti-HBs was between 0.96% and 3.40%, and showed no downward trend with the prolongation of immunization time (χ ~ 2 = 3.457, P = 0.063). The positive rate of Anti-HBs was between 20.11% and 89.72% Downtrend (χ ~ 2 = 797.206, P <0.001). Conclusion Newborn blood Hep B immunization with better durability, 28 years after immunization without strengthening the immune.