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【目的】探讨中药复方益肾活血解毒汤对实验性动脉粥样硬化(AS)家兔血清炎症标志物的影响及其抗AS的可能作用机制。【方法】将24只青紫蓝兔随机分为2组,空白对照组6只,造模组18只,复制AS模型,共6周;将造模成功的18只家兔随机分为益肾活血解毒汤组(剂量为7.5 g.kg-1.d-1)、辛伐他汀组(剂量为1.7 mg.kg-1.d-1)、模型对照组,每组均6只,于第7周分别予以益肾活血解毒汤、辛伐他汀液、生理盐水灌胃,共6周。分别于第6周、12周结束时抽血检测各组家兔血清炎症标志物的含量。【结果】造模结束后,模型组家兔血清白细胞介素-6(IL-6),超敏C反应蛋白(hs-CRP)水平升高、白细胞介素-10(IL-10)水平下降,与空白对照组比较有显著性差异(P<0.01)。给药结束后益肾活血解毒汤组和辛伐他汀组IL-6、hs-CRP水平降低,IL-10水平升高,与模型对照组比较具有显著性差异(P<0.05或P<0.01)。【结论】益肾活血解毒汤对实验性动脉粥样硬化家兔血清炎症标志物具有一定的干预作用。
【Objective】 To investigate the effects of Yishen Huoxue Jiedu Decoction, a traditional Chinese medicine compound, on the serum inflammatory markers in rabbits with experimental atherosclerosis (AS) and the possible mechanism of anti-AS. 【Methods】 Twenty-four rabbits were randomly divided into 2 groups: 6 in the control group and 18 in the modeling group. The AS model was replicated for 6 weeks. The 18 rabbits were randomly divided into the Yishen Huoxue group. Detoxification decoction group (dose 7.5 g.kg-1.d-1), simvastatin group (dose 1.7 mg.kg-1.d-1), model control group, 6 in each group, in the 7th Weekly administration of Yishen Huoxue Jiedu Decoction, simvastatin solution and saline to gavage for 6 weeks. At the end of the 6th and 12th week, blood samples were taken to detect the serum inflammatory markers in each group. 【Results】 After the model was established, the serum levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and interleukin-10 (IL-10) levels in the rabbits of the model group were decreased. There was a significant difference from the blank control group (P<0.01). After the administration, IL-6 and hs-CRP levels were decreased and IL-10 levels were increased in Yishen Huoxue Jiedu Decoction group and simvastatin group, which was significantly different from the model control group (P<0.05 or P<0.01). . 【Conclusion】 Yishen Huoxue Jiedu Decoction has certain intervention effects on experimental inflammatory markers in rabbits with atherosclerosis.