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用α-萘异硫氰酸盐(ANIT)造成大鼠急性肝内胆汁郁滞模型后,通过不同途径和不同时间的给药方法,投与疏肝酶,通过光镜与电镜观察大鼠肝脏内胆管系统与肝细胞的病理变化,同时进行血清总胆红质、碱性磷酸酶、谷丙酶的检测。结果表明,疏肝酶能减轻肝内胆小管的炎症性增生和胆小管上皮细胞的变性坏死,使胆小管管腔疏通,改善实验性胆汁郁滞状态。本实验为疏肝酶对高黄郁胆的临床治疗提供依据。
After an acute intrahepatic cholestatic model in rats was induced by α-naphthalene isothiocyanate (ANIT), liver enzymes were administered by different routes and at different times, and the livers were observed by light and electron microscopy. The pathological changes of the bile duct system and hepatocytes were detected simultaneously with serum total bilirubin, alkaline phosphatase and glialase. The results showed that SSG can reduce the inflammatory hyperplasia of bile canaliculi in the liver and degeneration and necrosis of bile duct epithelial cells, so that the lumen of the bile canal can be dredged and the state of experimental cholestatic stagnation can be improved. This experiment provides a basis for the clinical treatment of hyperglycemia with liver enzymes.