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目的比较前列腺特异性抗原密度(PSAD)、前列腺移行带抗原密度(PSAD-TZ)、前列腺特异性抗原(PSA)及游离前列腺特异性抗原和总前列腺特异性抗原比值(FPSA/TPSA)、在良性前列腺增生(BPH)和前列腺癌(PCa)鉴别诊断中的作用。方法55例BPH和23例PCa病人,PSA为4～20ng/ml,比较PSA、PSAD、FPSA/TPSA、PSAD-TZ指标,并进行统计学分析比较。结果BPH和PCa两组PSA平均值分别为(9.41±3.25)ng/ml和(11.29±2.50)ng/ml,两组比较P>0.05。两组PSAD平均值分别为(0.14±0.09)和(0.23±0.11),两组比较P<0.05。两组FPSA/TPSA平均值分别为(0.61±0.23)和(0.25±0.14),两组比较P<0.05。两组PSAD-TZ平均值分别为(0.25±0.19)和(0.52±0.25),两组比较P<0.01。结论PSAD、FPSA/TPSA、PSAD-TZ对PSA<20ng/ml的前列腺良、恶性病变具有鉴别作用,其中尤以PSAD-TZ更为准确。
Objective To compare the correlation between prostate specific antigen density (PSAD), prostatic transitional antigen density (PSAD-TZ), prostate specific antigen (PSA), free PSA and total prostate specific antigen ratio (FPSA / TPSA) Prostate hyperplasia (BPH) and prostate cancer (PCa) differential diagnosis. Methods 55 cases of BPH and 23 cases of PCa patients with PSA of 4 ~ 20ng / ml, compared PSA, PSAD, FPSA / TPSA, PSAD-TZ indicators, and statistical analysis. Results The mean PSA levels in both BPH and PCa groups were (9.41 ± 3.25) ng / ml and (11.29 ± 2.50) ng / ml, respectively. P> 0.05. The mean PSAD scores of the two groups were (0.14 ± 0.09) and (0.23 ± 0.11) respectively, P <0.05. The mean FPSA / TPSA scores of the two groups were (0.61 ± 0.23) and (0.25 ± 0.14) respectively, P <0.05. The average PSAD-TZ of the two groups were (0.25 ± 0.19) and (0.52 ± 0.25), respectively, P <0.01. Conclusions PSAD, FPSA / TPSA and PSAD-TZ have differential effects on benign and malignant prostatic lesions of PSA <20ng / ml, especially PSAD-TZ.