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作者用双盲法将12名18～24月龄儿童随机分为两组,分别接种DT-百日咳无细胞菌苗或DT-百日咳全菌体菌苗作为加强免疫。这些婴儿分别在2、4和6月龄接种过3次DTP。本试验旨在比较两种菌苗接种后的副反应及血清学应答。试验结果表明,两组免疫儿童无1人发生严重的全身及局部反应。接种百日咳无细胞菌苗组发热发生率低于接种百日咳全菌体菌苗组(P=0.00008),发热反应发生率高峰在免疫后6小时。无细胞菌苗组最高体温为38.9℃,全菌体菌苗组为40℃。免疫后24小
Twelve blind children aged 18 to 24 months were randomly divided into two groups and were vaccinated with DT-pertussis acellular bacterin or DT-pertussis whole body bacterin, respectively, for boosting. These infants received 3 DTPs at 2, 4 and 6 months of age respectively. The aim of this study was to compare side effects and serological responses after vaccination with both vaccines. The experimental results show that no one of the two immunized children developed severe systemic and local reactions. The incidence of fever in the acellular pertussis vaccinated group was lower than that in the whole bacillus vaccine group (P = 0.00008). The peak incidence of fever was 6 hours after immunization. The highest temperature in the acellular vaccine group was 38.9 ℃, and the whole bacterium vaccine group was 40 ℃. 24 hours after immunization