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目的:观察右美托咪定对直肠癌术后镇痛效果的影响。方法:选择择期直肠癌手术患者60例,随机分为观察组和对照组,观察组麻醉诱导前给予右美托咪定0.5μg/kg,继以0.2μg/(kg.h)持续输注至术毕;对照组给予等量生理盐水。术后予以舒芬太尼自控静脉镇痛(PCIA),观察术后不同时点视觉模拟评分(VAS)、痛阈值、皮质醇浓度及舒芬太尼用量,比较两组指标差异。结果:观察组VAS评分、皮质醇浓度和舒芬太尼用量低于对照组,痛阈值无明显差异。结论:预注0.5μg/kg右美托咪定并术中输注0.2μg/(kg.h),可以增加直肠癌术后舒芬太尼的镇痛效果。
Objective: To observe the effect of dexmedetomidine on postoperative analgesia of rectal cancer. Methods: Sixty patients undergoing elective rectal cancer surgery were randomly divided into observation group and control group. The observation group was given dexmedetomidine 0.5μg / kg before induction of anesthesia, followed by continuous infusion of 0.2μg / (kg.h) The patients in the control group were given the same amount of saline. Postoperative sufentanil-controlled intravenous analgesia (PCIA) was performed. The visual analogue scale (VAS), pain threshold, cortisol concentration and the amount of sufentanil were observed at different time points after operation. The differences between the two groups were compared. Results: The VAS score, cortisol concentration and the amount of sufentanil in the observation group were lower than those in the control group. There was no significant difference in the pain threshold. Conclusion: The injection of 0.5 μg / kg dexmedetomidine and intraoperative infusion of 0.2 μg / (kg · h) can increase the analgesic efficacy of sufentanil in patients with rectal cancer.