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感染性心内膜炎是由病原微生物循血行途径引起的心内膜、心瓣膜或邻近大动脉内膜的感染并伴赘生物的形成。感染性心内膜炎的病原微生物近几年已有明显变化。过去最主要的草绿色链球菌现已减少(<50%);葡萄球菌、革兰阴性杆菌、厌氧球菌、肠球菌等的感染性心内膜炎增加趋势。对于抗生素的应用原则,主要有:用药要早、剂量要足、疗程宜长、选用杀菌剂、监测血清杀菌滴度调整药物剂量、联合用药等。
Infective endocarditis is caused by pathogenic microorganisms through the bloodstream of endocardial, heart valve or adjacent intima of the intima and the formation of neoplasms. Infectious endocarditis pathogenic microorganisms have been significantly changed in recent years. In the past the most important Streptococcus viridans has now been reduced (<50%); Staphylococcus aureus, Gram-negative bacilli, anaerobic bacteria, enterococci and other infectious endocarditis increased. For the application of antibiotics, there are: medication should be early, the dose should be sufficient, the course should be long, the choice of fungicides, serum titer monitoring to adjust the dose of drugs, combination therapy.