肿瘤生长需要新生血管Folkman于1971年提出实体性肿瘤的生长需要新生血管的支持,它为肿瘤细胞的生长带来氧和营养物质,带走代谢产物。恶性肿瘤的远处转移也与之有关。实验证实,将肿瘤与血管分离,阻止血管新生时,肿瘤体积仅能长到1～2mm3,而一旦恢复血供,肿瘤迅速生长。现已明确 Tumor growth requires new blood vessels Folkman proposed in 1971 that the growth of solid tumors requires the support of new blood vessels, which brings oxygen and nutrients to the growth of tumor cells and takes away metabolites. The distant metastasis of malignant tumors is also relevant. Experiments have confirmed that when the tumor is separated from the blood vessel and the angiogenesis is prevented, the tumor volume can only grow to 1 to 2 mm3, and once the blood supply is restored, the tumor rapidly grows. It is now clear