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目的探讨血清鳞状细胞癌抗原(SCC)与胱抑素C(CysC)在慢性肾脏病(CKD)患者的变化及临床价值。方法选取110例CKD患者(研究组)及同期100例健康体检者(对照组)作为研究对象,按照肾小球滤过率将CKD患者分为CKD1期25例,CKD2期22例,CKD3期26例,CKD4期18例,CKD5期19例;检测各组研究对象的血清SCC,CysC、肌酐和尿微量白蛋白(mALB)水平,分析CKD患者血清SCC与CysC的变化及其相关性。结果研究组中患者血清SCC、CysC、肌酐及mALB水平显著高于对照组,差异均有统计学意义(P<0.05),并且CKD患者血清SCC、CysC、肌酐及mALB水平随着CKD分期的增加而明显升高,各分期间差异均具有统计学意义(P<0.05);血清SCC水平与CysC、肌酐及mALB均呈正相关(r=0.764,r=0.692,r=0.655,P<0.05)。结论 CKD患者血清SCC、CysC、肌酐及mALB水平均显著升高,并随着CKD分期的增加而增加,并且血清SCC与CysC、肌酐及mALB均成正相关,因此对CKD的诊断有重要的临床价值。
Objective To investigate the changes and clinical value of serum squamous cell carcinoma antigen (SCC) and cystatin C (CysC) in patients with chronic kidney disease (CKD). Methods One hundred and ten patients with CKD (study group) and 100 healthy subjects (control group) were enrolled in this study. According to the glomerular filtration rate, CKD patients were divided into 25 cases of CKD stage 1, 22 cases of CKD stage 2, 26 cases of CKD stage 2 In this study, 18 cases of CKD stage 4 and 19 cases of CKD stage 5 were enrolled in this study. Serum levels of SCC, CysC, creatinine and urine microalbumin (MALB) were measured in all the subjects. The changes and correlations of serum SCC and CysC in CKD patients were analyzed. Results The levels of serum SCC, CysC, creatinine and mALB in the study group were significantly higher than those in the control group (P <0.05), and the levels of SCC, CysC, creatinine and mALB were increased with the increase of CKD stage (P <0.05). There was a positive correlation between serum SCC level and CysC, creatinine and mALB (r = 0.764, r = 0.692, r = 0.655, P <0.05). Conclusions Serum levels of SCC, CysC, creatinine and mALB were significantly increased in patients with CKD and increased with the increase of CKD staging. Serum SCC was positively correlated with CysC, creatinine and mALB, and therefore had an important clinical value in the diagnosis of CKD .