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目的观察紫杉醇治疗晚期肿瘤的临床疗效及不良反应。方法对2009年1月～2010年7月门诊化疗中心收治的198例接受紫杉醇治疗的晚期肿瘤患者临床资料进行回顾性分析,统计临床治疗效果及不良反应。结果 198例患者中,完全缓解(CR)29例,部分缓解(PR)90例,稳定(SD)52例,进展(PD)27例,临床治疗有效率60.1%。198例患者均出现骨髓抑制、不同程度的脱发;160例出现消化道反应;133例出现肌肉关节疼痛;124例患者发生周围神经毒性;15例患者发生轻度肾功能损害;3例出现过敏反应。结论含紫杉醇的化疗方案是治疗晚期肿瘤的有效方法。
Objective To observe the clinical efficacy and side effects of paclitaxel in the treatment of advanced cancer. Methods A retrospective analysis was performed on the clinical data of 198 advanced cancer patients treated with paclitaxel admitted to the outpatient chemotherapy center between January 2009 and July 2010. The clinical effects and adverse reactions were statistically analyzed. Results Of the 198 patients, 29 were completely relieved (CR), 90 were partially relieved (PR), 52 were stable (SD) and 27 were PD. The effective rate of clinical treatment was 60.1%. 198 patients had myelosuppression, varying degrees of hair loss; gastrointestinal reactions in 160 patients; muscle pain in 133 patients; peripheral neurotoxicity in 124 patients; mild renal impairment in 15 patients; and allergic reactions in 3 patients . Conclusion paclitaxel-containing chemotherapy is an effective method for the treatment of advanced cancer.