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目的探讨血清肺炎衣原体IgA抗体水平与缺血性脑卒中发生的关系。方法采用病例对照研究的方法,对2002年10月至2004年7月中国医科大学附属第一医院临床流行病学教研室从彰武县农村调查发现的符合入选标准的117例缺血性脑卒中患者中随机抽取76例作为病例组,同时从该调查人群中选取80例与病例组相匹配的无脑卒中史者作为对照组,每人采血5mL,采用EIA试剂盒进行血清肺炎衣原体IgA抗体的检测。结果(1)病例组与对照组肺炎衣原体IgA抗体EIU均值分别为45.56±40.95和48.75±40.72,差异无显著性(P>0.05)。(2)病例组与对照组肺炎衣原体IgA抗体阳性率分别为72.4%和75.0%,两组间差异无显著性(P>0.05),优势比OR=0.873(95%可信区间0.428～1.782)。(3)对缺血性脑卒中发生及其危险因素的多元Logistic回归分析,得到的调整IgA抗体阳性率与缺血性脑卒中的关系仍无显著性意义。结论肺炎衣原体抗体与缺血性脑卒中发生可能无关联。
Objective To investigate the relationship between serum Chlamydia pneumoniae IgA antibody levels and the occurrence of ischemic stroke. Methods A case-control study was conducted. From October 2002 to July 2004, 117 cases of ischemic stroke patients who met the inclusion criteria and were found in the survey of rural epidemiology of the First Affiliated Hospital of China Medical University from the Zhangwu County, In which 76 cases were selected randomly as the case group. At the same time, 80 cases of stroke-free history matched with the case group were selected as the control group. Blood samples were collected from 5 mL each. EIA kit was used to detect serum Chlamydia pneumoniae IgA antibody . Results (1) The mean EIU of Chlamydia pneumoniae IgA antibodies in case group and control group were 45.56 ± 40.95 and 48.75 ± 40.72, respectively, with no significant difference (P> 0.05). (2) The positive rates of IgA antibody of Chlamydia pneumoniae in case group and control group were 72.4% and 75.0% respectively, there was no significant difference between the two groups (P> 0.05). The odds ratio was 0.873 (95% confidence interval 0.428-1.782) . (3) Multivariate Logistic regression analysis showed that the relationship between IgA antibody positive rate and ischemic stroke was not significant. Conclusions Chlamydia pneumoniae antibodies may not be associated with ischemic stroke.