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瘦素是肥胖基因编码的一种蛋白，由脂肪细胞分泌，通过与瘦素受体结合发挥生物活性效应，其主要作用是调节营养物质代谢如糖类、脂类，调节能量平衡，促使机体抑制食欲，促进能量消耗，减少脂肪细胞合成，降低体质量。冠状动脉慢血流现象是指在冠状动脉造影过程中，冠状动脉无明显狭窄病变，而远端血流灌注延迟的现象。诸多研究表明瘦素可能参与冠状动脉慢血流现象的发生、发展，现就近年来瘦素参与冠状动脉慢血流的发病机制做一综述。“,”Leptin is a protein coded by obesity gene,which is secreted by adipose cells and plays an important biological activity role by binding to specific leptin receptors.Its main functions are to regulate metabolism of nutrients such as sugar and fat.It can regulate energy metabolism,suppress the appetite, promote energy consumption and decrease adipose cell synthesis thereby enabling weight loss.Coronary slow flow phenomenon is characterized by delayed opacification of coronary vessels in a normal coronary angiogram.Many studies have indica-ted that leptin may participate in the occurrence and development of coronary slow flow phenomenon.This article reviews the recent findings that leptin involved the pathogenic mechanism of coronary slow flow phenomenon.