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目的 探讨胎儿生长迟缓 (IUGR)时母血、脐血中维生素A(VitA)水平的变化以及对新生儿视力发育的影响。方法 采用微量荧光法测定IUGR组和正常对照组各 30例孕妇母血、脐血血清中VitA含量 ,并对所有新生儿采用闪光视觉诱发电位 (F VEP)检测新生儿视功能发育状况。结果 IUGR组母血、脐血中VitA含量均低于正常对照组 (P <0 0 1) ,且母血、脐血中VitA含量两者之间相关性 ,r =0 80 99、P <0 0 1;母血、脐血中VitA含量与新生儿体重呈正相关 (P <0 0 1)。F VEP检测IUGR组P10 0潜伏期较正常对照组延长 (P <0 0 5 ) ,而幅值则低于对照组 (P <0 0 1) ;P10 0潜伏期与新生儿体重呈负相关 ,而幅值与新生儿体重呈正相关。结论 提示IUGR时小于胎龄儿 (SGA)视觉发育受到影响 ,该影响发生与母血、脐血中VitA含量下降有关
Objective To investigate the changes of vitamin A (VitA) levels in maternal blood and umbilical cord blood during fetal growth retardation (IUGR) and their effects on visual acuity. Methods The serum levels of VitA in maternal blood and umbilical cord blood of 30 pregnant women in IUGR group and normal control group were measured by micro-fluorescence method. Visual FVEP was used to detect visual function in neonates. Results The levels of VitA in maternal serum and umbilical blood were lower in IUGR group than those in normal control group (P <0.01) and in maternal blood and umbilical cord blood (r = 0 80 99, P <0 The serum VitA level in maternal blood and umbilical cord blood was positively correlated with the weight of neonates (P <0.01). F VEP detected P10 0 latency in IUGR group was longer than that in control group (P <0.05), but amplitude was lower than that in control group (P <0.01); P10 latency was negatively correlated with neonatal body weight The value is positively correlated with the newborn’s body weight. The results suggest that the visual development of SGA in IUGR is affected, which is related to the decrease of VitA in maternal and umbilical blood