目的评价骨化三醇冲击和每日治疗对继发甲状旁腺功能亢进(SHPT)的疗效。方法选择肾功能不全72例血液透析患者,血甲状旁腺激素(iPTH)水平>300 pg/ml,随机分为冲击组和每日组,分别采用骨化三醇2μg 1周2次和0.5μg,1次/d,观察24周,检测治疗前后血PTH及钙磷代谢相关指标。结果血清iPTH均发生变化,冲击组AKP(碱性磷酸酶),iPTH指标明显下降,钙,磷两组治疗前后无明显差异,均不良反应轻微。结论骨化三醇能有效控制SHPT,安全性好,冲击法对SHPT患者疗效更显著。 Objective To evaluate the efficacy of calcitriol challenge and daily treatment on secondary hyperparathyroidism (SHPT). Methods 72 cases of hemodialysis patients with renal dysfunction, blood parathyroid hormone (iPTH) level> 300 pg / ml, were randomly divided into the impact group and the daily group, respectively, calcitriol 2μg twice a week and 0.5μg , 1 time / d, observed for 24 weeks, before and after treatment to detect blood PTH and calcium and phosphorus metabolism-related indicators. Results Serum iPTH changes, the impact of the group of AKP (alkaline phosphatase), iPTH index decreased significantly, calcium, phosphorus two groups before and after treatment no significant difference, were mild adverse reactions. Conclusion Calcitriol can effectively control SHPT, and its safety is good. The impact method is more effective on patients with SHPT.