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目的探讨胃肠道间质瘤的诊断和治疗方式及影响术后复发的因素。方法对我院2001年1月～2007年6月收治并获随访的71例胃肠道间质瘤的临床资料进行回顾性分析。分别采用单因素和多因素两种方式对影响复发的因素进行分析。结果单因素分析显示,肿瘤大小、有无浸润、坏死和手术方式均对术后复发有影响(P<0.05);多因素分析显示,肿瘤大小、有无浸润和手术方式对术后复发有影响(P<0.05)。结论适当扩大切除范围,术后服用依马替尼可降低胃肠道间质瘤的术后复发率,改善病人预后。
Objective To investigate the diagnosis and treatment of gastrointestinal stromal tumors and the factors influencing postoperative recurrence. Methods The clinical data of 71 cases of gastrointestinal stromal tumors admitted to our hospital from January 2001 to June 2007 were retrospectively analyzed. The factors influencing the recurrence were analyzed by single factor and multiple factors respectively. Results Univariate analysis showed that tumor size, infiltration, necrosis and surgical methods all had an effect on postoperative recurrence (P <0.05). Multivariate analysis showed that the size of tumor, infiltration without invasion and surgical modality had an effect on postoperative recurrence (P <0.05). Conclusion Appropriate expansion of the excision range, after taking imatinib can reduce gastrointestinal stromal tumor recurrence rate and improve prognosis.