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目的探讨总胆固醇(CHO)降低在重型肝炎诊治中的临床意义、发生机制和对预后的影响。方法检测82例重型肝炎患者和65例健康对照组的血清CHO水平。根据预后不同将患者分为死亡组和存活组,又根据CHO降低程度将患者分为轻、中、重度三种。从CHO水平和CHO降低的严重程度来比较重型肝炎患者的预后转归。结果重型肝炎患者与对照组的CHO水平分别为(2.8±0.9)mmol/L、(4.7±0.7)mmol/L,两组相比P<0.01;死亡组和存活组血清钠水平分别为(1.5±0.6)mmol/L、(2.9±0.8)mmol/L,两组相比P<0.01;轻、中、重度低CHO组的病死率分别为21.86%、56.41%、90.91%,三组相互之间比较P<0.01。结论CHO是反映肝脏受损的情况及预后估计的敏感指标,其发生的严重程度与肝功能受损程度、病情转归、预后密切相关。密切监测CHO指标的变化,对于改善重型肝炎患者的预后、提高生存率有重要意义。
Objective To investigate the clinical significance, mechanism and prognosis of total cholesterol (CHO) reduction in the diagnosis and treatment of severe hepatitis. Methods Serum CHO levels were measured in 82 patients with severe hepatitis and 65 healthy controls. The patients were divided into death group and survival group according to the different prognosis. According to the reduction of CHO, the patients were divided into three groups: mild, moderate and severe. The prognosis of patients with severe hepatitis was compared with the severity of CHO and CHO reduction. Results The levels of CHO in severe hepatitis and control group were (2.8 ± 0.9) mmol / L and (4.7 ± 0.7) mmol / L respectively, P <0.01; ± 0.6) mmol / L and (2.9 ± 0.8) mmol / L, respectively, P <0.01; the mortality of low, moderate and severe low CHO groups were 21.86%, 56.41% and 90.91% Between the two P <0.01. Conclusion CHO is a sensitive indicator of liver damage and prognosis. The severity of the disease is closely related to the degree of liver damage, prognosis and prognosis. To closely monitor the changes of CHO index is of great significance to improve the prognosis and improve the survival rate of patients with severe hepatitis.