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目的观察分析妊娠合并肝内胆汁淤积症的临床诊治方法及母婴影响,总结其临床意义。方法选取我院2009年8月至2011年9月妊娠期肝内胆汁淤积症的孕妇45例,设为观察组,再选取同期孕检正常的孕妇45例,设为对照组,观察比较两组血中ALT、AST、甘胆酸水平,终止妊娠孕周/分娩孕周、分娩方式及母儿结局。结果观察组孕妇血中的ALT、AST、甘胆酸水平明显高于对照组,两组比较差异明显(P<0.05),具有统计学意义;观察组剖宫产率、产后出血率、羊水粪染发生率、新生儿窒息率、围生儿死亡率比较差异明显(P<0.05),具有统计学意义;两组终止妊娠孕周/分娩孕周、新生儿Apgar评分比较差异明显(P<0.05),具有统计学意义。结论肝内胆汁淤积症对母儿结局有明显影响,全面加强孕期筛查,早期诊断,早期对症处理是预防母儿并发症发生,减少围生儿死亡,提高新生儿存活率的关键,对保障母婴安全具有重要的临床意义。
Objective To observe the clinical diagnosis and treatment of intrahepatic cholestasis of pregnancy and maternal and infant influence, summarize its clinical significance. Methods Forty-five pregnant women with intrahepatic cholestasis of pregnancy in our hospital from August 2009 to September 2011 were selected as observation group and 45 pregnant women with normal pregnancy test in the same period were selected as control group. Blood ALT, AST, glycocholic acid levels, termination of gestational gestational weeks / gestational gestational age, mode of delivery and maternal and child outcomes. Results The blood levels of ALT, AST and glycocholic acid in the observation group were significantly higher than those in the control group, with significant difference between the two groups (P <0.05), with statistical significance. The cesarean section rate, postpartum hemorrhage rate, (P <0.05), with statistical significance; Apgar score of newborn infants showed significant difference (P <0.05) between gestational weeks of gestation and gestation ),has statistical significane. Conclusion Intrahepatic cholestasis has a significant effect on maternal and child outcomes. Comprehensive screening for pregnancy, early diagnosis and early symptomatic treatment are the keys to prevent complications of maternal and neonatal diseases, reduce perinatal mortality and improve the survival rate of newborn infants. Maternal and child safety has important clinical significance.