论文部分内容阅读
目的了解浙江省金华市本地人群与外来人群麻疹免疫水平,为制定消除麻疹策略提供科学依据。方法以乡镇或居委会为单位,分<1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、≥20岁7个年龄组,本地人群每个年龄组抽取90人,共630人;外来人群每个年龄组抽取30人,共210人。以此840人为监测对象,采集合格血清标本,用酶联免疫吸附试验定量检测麻疹IgG抗体,同时调查麻疹患病史、麻疹疫苗免疫史及基本情况。结果本地人群的麻疹抗体阳性率、保护率和几何平均浓度(GMC)分别为92.54%、78.73%和1774.19 mIU/ml;外来人群的麻疹抗体阳性率、保护率和GMC分别为66.67%、40.95%和269.90 mIU/ml。本地人群的阳性率、保护率和GMC均明显高于外来人群(P=0.000)。本地人群的疫苗接种率为82.38%(519/630),显著高于外来人群的12.86%(27/210)(χ2=333.75,P=0.000)。结论金华市本地人群麻疹免疫水平较高,外来人群的麻疹疫苗接种率不高,麻疹抗体水平明显低于本地人群。必须采取“加强流动儿童免疫接种管理、开展应急接种、给外来新生和新员工接种麻苗”等综合措施,来全面提高外来人群的麻疹抗体水平。
Objective To understand the level of measles immunity of local population and non-native population in Jinhua City, Zhejiang Province, and to provide a scientific basis for formulating measles elimination strategy. Methods The township and neighborhood committees were divided into seven groups: <1 year old, 1 ~ 2 years old, 3 ~ 4 years old, 5 ~ 6 years old, 7 ~ 14 years old, 15 ~ 19 years old, ≥ 20 years old, The age group of 90 people, a total of 630 people; foreign population of 30 people in each age group, a total of 210 people. 840 people were taken as the monitoring object to collect the qualified serum samples. The measles IgG antibody was detected quantitatively by enzyme-linked immunosorbent assay. Meanwhile, the history of measles, the immunization history of measles vaccine and the basic situation were investigated. Results The positive rate, protective rate and geometric mean concentration (GMC) of measles antibody in local population were 92.54%, 78.73% and 1774.19 mIU / ml, respectively. The positive rate, protective rate and GMC of measles antibody were 66.67% and 40.95% And 269.90 mIU / ml. The local population’s positive rate, protection rate and GMC were significantly higher than those of foreign population (P = 0.000). The local population vaccination rate was 82.38% (519/630), significantly higher than that of the alien population (27/210) (χ2 = 333.75, P = 0.000). Conclusions The level of measles immunity in local population of Jinhua City is high, the measles vaccination rate is not high in foreign population, and the level of measles antibody is obviously lower than that in local population. We must take comprehensive measures such as “strengthening the management of immunization of migrant children, carrying out emergency vaccination, and giving newborn infants and new staff vaccination with” to comprehensively raise the measles antibody level of the foreign population.