【摘 要】
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Dear Editor,rnKlinefelter syndrome (KS) is the most frequent genetic cause of infertility in men.Paternity can be achieved through intracytoplasmic sperm injection (ICSI) with spermatozoa recovered from ejaculated semen if exist,or testes with testicular
【机 构】
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Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Sh
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Dear Editor,rnKlinefelter syndrome (KS) is the most frequent genetic cause of infertility in men.Paternity can be achieved through intracytoplasmic sperm injection (ICSI) with spermatozoa recovered from ejaculated semen if exist,or testes with testicular sperm extraction (TESE).Though the proportion of spermatozoa and embryos with abnormal sex chromosomes and autosomes,especially chromosomes 13,18 and 21,is higher in KS patients as reported,1 which suggests the need of preimplantation genetic diagnosis (PGD),the application of PGD becomes questionable with more and more normal babies born with ICSI without PGD.This article aims to report the results of 13 ICSI-PGD cycles performed in 13 KS patients with ejaculated spermatozoa in the authors\' reproductive center and to discuss the necessity of application of PGD in comparison with the outcomes of ICSI with or without PGD in KS patients in literature (P ＜ 0.05 was considered to be statistically significant).
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