[目的]比较不同方法对肝源性溃疡的疗效。[方法]将40例肝源性溃疡患者根据不同治疗方法分为A组、B组、C组,分别予以心得安+洛赛克、消心痛+洛赛克、单用洛赛克治疗,疗程均为28d。观察各组溃疡部位,治疗前后幽门螺杆菌(Hp)感染率,溃疡愈合情况及治疗后1年以内、3年以内上消化道大出血发生率。[结果]各组胃溃疡的发病者均明显多于球部溃疡者。各组治疗前后Hp感染率比较无差异(P>0.05)。治疗后溃疡愈合率A组高于C组(P<0.05);B组也高于C组,但2组比较差异无统计学意义(P>0.05)。A组、B组在1年、3年以内上消化道出血率均明显低于C组(P<0.01)。[结论]心得安或消心痛联合洛赛克治疗有助于肝源性溃疡的愈合,同时可减少肝硬化并发上消化道出血发病率。 [Objective] To compare the curative effect of different methods on liver-derived ulcer. [Method] 40 patients with liver-derived ulcer were divided into A group, B group and C group according to different treatment methods, respectively treated with propofol + Losec, ambroxol + Losec, and Losec alone. The course of treatment Are 28d. Observe the ulcer site, the infection rate of Helicobacter pylori (Hp) before and after treatment, ulcer healing and within 1 year after treatment, the incidence of upper gastrointestinal bleeding within 3 years. [Results] The incidences of gastric ulcer in each group were significantly more than those in ulcer. There was no difference in Hp infection rate between before and after treatment (P> 0.05). The healing rate of ulcer after treatment was higher in group A than in group C (P <0.05); group B was also higher than group C, but there was no significant difference between the two groups (P> 0.05). The rates of upper gastrointestinal bleeding in group A and group B in one year and three years were significantly lower than those in group C (P <0.01). [Conclusion] The combination of propranolol or echocardiography combined with Losec can help the healing of liver-derived ulcer and reduce the incidence of upper gastrointestinal bleeding in patients with cirrhosis.