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目的 评价新研制成功的国产冻干风疹减毒活疫苗的免疫持久性 ,为制定风疹疫苗免疫策略提供依据。方法 在桃江县城关镇三所小学选择 5～ 9岁风疹血清HI抗体阴性的健康儿童 ,为其接种风疹疫苗 ,跟踪观察风疹疫苗免疫后抗体动态变化。结果 免疫 1个月后风疹HI抗体的阳转率为 98 94% ,抗体几何平均滴度倒数 (GMT)为877 79。免后 1、 2、 3、 4、 5年风疹HI抗体阳性率仍维持较高水平 ,分别为 99 2 1%、 10 0 0 0 %、 10 0 0 0 %、10 0 0 0 %、 10 0 0 0 % ;而风疹HI抗体的GMT则逐年下降 ,分别为 767 18、 5 5 0 18、 3 63 0 8、 2 2 3 92、 15 8 42 ;第 8年风疹HI抗体阳性率和GMT均明显下降 ,分别为 91 3 0 %和 3 0 96。结论 国产冻干风疹减毒活疫苗具有良好的免疫原性 ,免疫效果至少可维持 8年。
Objective To evaluate the immune persistence of the newly developed domestic freeze-dried rubella attenuated live vaccine and provide evidence for the development of rubella vaccine immunization strategy. Methods In three primary schools in Chengguan Town, Taojiang County, rubella sera were screened for the rubella vaccination of healthy children aged 5 ~ 9 years with rubella sera. The changes of antibody after rubella vaccination were observed. Results After 1 month of immunization, the positive rate of rubella HI antibody was 98 94%, and the geometric mean antibody titer (GMT) was 877 79. The positive rates of rubella HI antibodies remained high at 1, 2, 3, 4 and 5 years after immunization (99 2 1%, 100 0%, 100 0%, 100 0%, 100 The GMT of rubella HI antibody decreased year by year, which were 767 18, 55 0 18, 3 63 0 8, 2 2 3 92 and 15 8 42, respectively. The positive rate of rubella HI antibody and GMT in the 8th year were all significant Decline was 91 30% and 3 0 96 respectively. Conclusion The domestic freeze-dried rubella attenuated live vaccine has good immunogenicity, and the immune effect can be maintained for at least 8 years.