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一种有免疫功能的鼠/人嵌合型抗体——由鼠IgM可变区加正常人IgM稳定区组成的新型IgM五聚体已经产生,并对其若干特性进行了研究.用基因工程技术,由杂交瘤细胞Sp6-718品系提供小鼠抗半抗原三硝基苯酚(TNP)的μ链可变区的基因片段,由已克隆的噬菌体λC75提供表达正常人μ链稳
An Immunocompetent Mouse / Human Chimeric Antibody - A Novel IgM Pentamer consisting of a Murine IgM Variable Region plus a Normal Human IgM Stable Region Has Been Produced and Some of Its Properties Are Studied Gene engineering techniques , The gene fragment of the mouse microtubule variable region of mouse anti-hapten trinitrophenol (TNP) was provided by the hybridoma cell line Sp6-718. The cloned phage lambda C75 was used to provide stable