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双苄异奎啉类速效非去极化肌松药美维松的小儿剂量很少超过95％有效剂量(ED_(95))的2.5倍。小儿在N_2O-镇痛药麻醉或吸入麻醉时增大美维松的剂量,超效可增快并与剂量相关,但作用持续时间增加有限。不过,临床上用量一般不超过2.5×ED_(95),虽然小儿注用美维松3.0×ED_(95)仍能维持心血管稳定,但血浆组胺浓度(PHC)可能增多。为了研究小儿在异丙酚-N_2O麻醉下,注用美维松的作用以及组胺的情况,作者特选择体
Pediatric doses of bisbenzyl-isoquinoline, a rapidly acting non-depolarizing muscle relaxant, were rarely over 2.5-fold more than the 95% effective dose (ED 95). Pediatric N2O-analgesic anesthesia or inhalation anesthesia to increase the dose of mevonic acid, super efficiency can be increased and dose-related, but the role of the limited increase in duration. However, the clinical dose is generally not more than 2.5 × ED_ (95). Although pedicled with mevonic acid 3.0 × ED_ (95) still maintains cardiovascular stability, plasma histamine concentration (PHC) may increase. In order to study children under propofol-N_2O anesthesia, the use of mevonic acid injection and histamine,