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目的:探讨血清白细胞介素(IL)-6水平与多发性骨髓瘤(MM)及其MM骨病的关系。方法:MM组37例,其中0分组10例,1分组6例,2分组8例,3分组11例,用ELISA方法检测血清IL-6的水平。结果:①MM组和实体瘤骨转移组血清IL-6水平明显高于正常对照组(P<0.05);②各骨损评分组间IL-6水平差异有统计学意义(P<0.05);③血钙正常组和异常组间的IL-6水平存在显著不同(P<0.05)。结论:MM患者血清IL-6水平升高,且IL-6的水平与MM骨损程度密切相关。
Objective: To investigate the relationship between serum interleukin (IL) -6 level and multiple myeloma (MM) and its MM bone disease. Methods: Thirty-seven MM patients were included, including 10 cases in 0 group, 6 cases in 1 case, 8 cases in 2 cases and 11 cases in 3 cases. Serum IL-6 levels were detected by ELISA. Results: (1) The levels of IL-6 in MM group and solid tumor group were significantly higher than those in normal control group (P <0.05); (2) The IL-6 levels in each group were statistically significant (P < There was a significant difference in IL-6 levels between the normal serum calcium group and the abnormal calcium group (P <0.05). Conclusion: The level of serum IL-6 in patients with MM is increased, and the level of IL-6 is closely related to the degree of MM bone loss.