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目的探讨新生儿缺氧缺血性脑病(HIE)的发生、程度和预后与血清酶学变化的临床相关性。方法回顾中、重度HIE患儿106例血清酶学检测的结果。结果所有患儿均有血清酶活性不同程度升高,中、重度各酶值比较差异有统计学意义(P<0.05)。结论血清酶学变化测定对新生儿缺血缺氧性脑病早期诊断及预后有指导意义,可降低后遗症发生率和患儿病死率。
Objective To investigate the clinical significance of the occurrence, degree and prognosis of neonatal hypoxic-ischemic encephalopathy (HIE) and the changes of serum enzymology. Methods The results of 106 cases of severe HIE children with serum enzymatic examination were retrospectively reviewed. Results All patients had different levels of serum enzymatic activity increased, moderate and severe enzyme values were significantly different (P <0.05). Conclusion Serum enzyme changes in early diagnosis and prognosis of neonatal hypoxic-ischemic encephalopathy may be instructive, which can reduce the incidence of sequelae and mortality in children.