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目的比较中晚期食管癌患者放射治疗中联合或不联合康莱特注射液的耐受性。方法收集符合入选条件的患者60例,随机分为康莱特联合放疗组(联合组)和单一放疗组(对照组),联合组使用康莱特注射液(100 mL,静滴1次/d,d1～21,4周重复),主要观测指标为放射性食管炎、白细胞计数及患者KPS评分。结果联合组2、3级放射性食管炎发生率及总发生率均较低,血白细胞计数下降程度较小,且KPS评分较高,与对照组比较,差异有统计学意义(P<0.05)。结论三维适形放疗联合康莱特注射液能提高中晚期食管癌患者耐受性。
Objective To compare the tolerability of KLT with or without radiotherapy in patients with advanced esophageal cancer. Methods Sixty patients who met the inclusion criteria were randomly divided into Kanglaite combined radiotherapy group (combination group) and single radiotherapy group (control group). The combination group was given Kanglaite Injection (100 mL, intravenous infusion once a day, d1 ~ 21,4 weeks repeated), the main observation indicators of radiation esophagitis, white blood cell count and patient KPS score. Results The incidence and total incidence of radioesophageal esophagitis grade 2 and 3 in the combined group were lower, the white blood cell count decreased less, and the KPS score was higher. The difference was statistically significant (P <0.05). Conclusion Three-dimensional conformal radiotherapy combined with Kanglaite injection can improve the tolerance of patients with advanced esophageal cancer.