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大家都知道，长链ω-3不饱和脂肪酸（PUFA），特别是二十碳五烯酸（EPA）、甘二碳六烯酸（DHA）和甘二碳五烯酸（DPA）对人类健康具有重要意义。它们对心血管疾病和各种炎症具有生化和生理学的效果，因为它们是调节各种生物学功能的激素的直接前体。由于DHA对人的大脑和视网膜具有独特的功能，最近特别受重视。长链ω-3PUFA，尤其是DHA和EPA主要存在于各种鱼油中。鱼油的脂肪酸成分因不同的鱼种、不同的海域和捕捞季节而异。一般而言，在天然海鱼鱼油中大约有30%PUFA（主要是DNA和EPA）。如果用天然鱼油来提供长链ω-3PUFA，必须摄入大量的鱼油才能得到足够量的长链ω-3PUFA。因此，显然最好采用浓缩的长链PUFA，因为这样可以减少每日的脂肪摄入量。氢化油鲱油已被美国食品与药物管理局确认为公认安全无害的食物。近年来，药品与保健食品工业采用各种不同的方法来分离和提纯PUFA。分离提纯法主要有：1、色谱分离法；2、提取（萃取）法；3、真空分馏法；4、脲络合法。本文简要地总结了各种方法的优缺点。近年来PUFA的强化又成为大家关注的焦点。主要是用微生物脂酶来进行强化。本文对水解、酸解、醇解、酯—酯交换、酯化等酶促强化法分别作了介绍。所有这些酶促反应都是在常温、常压和氮保护环境条件下进
As we all know, long-chain ω-3 unsaturated fatty acids (PUFA), especially eicosapentaenoic acid (EPA), DHA and DPA are harmful to human health It is of great significance. They have a biochemical and physiologic effect on cardiovascular disease and various inflammation as they are direct precursors of hormones that regulate various biological functions. Due to the unique function of DHA on the human brain and retina, it has received special attention recently. Long chain omega-3 PUFAs, especially DHA and EPA, are found primarily in various fish oils. The fatty acid composition of fish oil varies according to species, sea area and fishing season. In general, there are about 30% PUFA (mainly DNA and EPA) in natural marine fish oil. If natural fish oil is used to provide long-chain ω-3 PUFA, large amounts of fish oil must be ingested to obtain a sufficient amount of long-chain ω-3 PUFA. Therefore, it is clearly best to use concentrated long-chain PUFA, as this will reduce your daily fat intake. Hydrogenated marinade has been recognized by the U.S. Food and Drug Administration as a safe and safe food. In recent years, the pharmaceutical and nutraceutical industries employ a variety of different methods to separate and purify PUFAs. Separation and purification methods are: 1, chromatographic separation; 2, extraction (extraction); 3, vacuum fractionation; 4, urea complex method. This article briefly summarizes the advantages and disadvantages of various methods. PUFA strengthening in recent years has become the focus of everyone’s attention. Mainly with microbial lipase to strengthen. In this paper, hydrolysis, acidolysis, alcoholysis, ester - transesterification, esterification and other enzymatic strengthening were introduced. All of these enzymatic reactions are performed at ambient temperature, atmospheric pressure and under nitrogen protection