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目的:探讨高频震荡通气治疗常频通气失败的新生儿持续肺动脉高压的临床治疗效果以及具体的安全性。方法:选取该院在2011年10月至2014年10月之间收治的常频机械通气治疗之后失败的新生儿22例,并且在治疗失败之后改为高频震荡通气治疗方式,对于患儿pH值情况的相关数据进行分析。结果:高频震荡通气治疗之前,所有患儿的各项指标均出现异常现象,高频震荡通气治疗之后,患儿的情况有所好转,同时动脉血液中的PH值也恢复了正常状态,在患儿接受高频震荡通气治疗前以及治疗之后的4、12、24、48 h的时间点上患儿身体情况均有所变化,差异具有统计学意义(P<0.05)。结论:经过对患儿临床资料的调查能够看出,常频通气治疗新生儿持续肺动脉高压病情不具有显著效果,经过高频震荡通气治疗之后,患儿身体的各项指标均恢复正常,且相对常频通气治疗更加安全有效。
Objective: To investigate the clinical effect and safety of high-frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension in neonates with frequent ventilatory failure. Methods: Twenty-two newborns who failed after the treatment of normal-frequency mechanical ventilation in our hospital from October 2011 to October 2014 were selected and treated with high-frequency oscillatory ventilation after treatment failure. Value of the relevant data for analysis. Results: Before high-frequency oscillatory ventilation, all the indicators of children showed abnormalities. After high-frequency oscillatory ventilation, the condition of children improved and the PH value in arterial blood returned to normal. The changes of physical condition in children before and after treatment with high-frequency oscillatory ventilation at 4, 12, 24 and 48 h after treatment were statistically significant (P <0.05). Conclusion: After the clinical data of children can be seen in the survey, frequent ventilatory treatment of neonatal pulmonary hypertension continued to have no significant effect, after high-frequency oscillatory ventilation treatment, the indicators of children with the body returned to normal, and relative Frequent ventilation treatment more safe and effective.