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肝纤维化的诊断目前仍以病理检查为主，但病理检查有其局限性。近年来对肝纤维化诊断的研究，多在寻找无创伤的血清学检查方法。为此本文用放射免疫法检测３０例不同类型病毒性肝炎血清Ⅳ型胶原（Ⅳ－Ｃ）和层粘连蛋白（ＬＮ）的变化，并与肝病理组织炎症活动度及纤维增生程度进行相关性分析。结果显示Ⅳ－Ｃ与炎症活动度呈正相关，而血清ＬＮ与炎症活动度无关；血清ＬＮ及Ⅳ－Ｃ水平均与纤维增生呈正相关。提示血清ＬＮ及Ⅳ－Ｃ可作为一种无创性的肝纤维化检测方法。
Liver fibrosis diagnosis is still the main pathological examination, but the pathological examination has its limitations. In recent years, the diagnosis of liver fibrosis research, mostly looking for non-invasive serological test. In this paper, radioimmunoassay was used to detect the changes of serum level of type Ⅳ collagen (Ⅳ-C) and laminin (LN) in 30 patients with different types of viral hepatitis, and to analyze the correlation between the degree of inflammatory activity and the degree of fibrosis . The results showed that there was a positive correlation between IV-C and inflammatory activity, but no correlation between serum LN and inflammatory activity. Serum LN and IV-C levels were positively correlated with fibrosis. Prompt serum LN and Ⅳ-C can be used as a noninvasive method of detection of liver fibrosis.