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目的探讨胆囊结石与代谢综合征的相关性。方法 2 716例体检者,其中1 298例有胆囊结石者为胆囊结石组,1 414例无胆囊结石者为对照组,比较2组年龄、三酰甘油、总胆固醇、收缩压、舒张压、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、体质量指数、空腹血糖水平。结果胆囊结石组年龄[(51.82±13.73)岁]、三酰甘油[(1.97±1.84)mmol/L]、总胆固醇[(4.95±1.03)mmol/L]、收缩压[(126.43±18.81)mmHg]、舒张压[(78.76±13.02)mmHg]、低密度脂蛋白胆固醇[(2.94±0.33)mmol/L]、体质量指数[(26.06±3.70)kg/m~2]、空腹血糖[(5.49±1.71)mmol/L]水平均高于对照组[(36.51±13.26)岁、(1.43±1.40)mmol/L、(4.50±1.00)mmol/L、(117.59±16.02)mmHg、(73.90±12.13)mmHg、(2.36±0.69)mmol/L、(23.46±3.65)kg/m~2、(5.14±0.96)mmol/L],高密度脂蛋白胆固醇水平[(1.24±0.33)mmol/L]低于对照组[(1.37±0.33)mmol/L](P<0.05);多因素logistic回归分析显示,年龄增长(OR=1.078,95%CI:1.070~1.086,P=0.000)、体质量指数增高(OR=2.166,95%CI:1.786~2.626,P=0.000)、高密度脂蛋白胆固醇水平降低(OR=2.045,95%CI:1.499~2.791,P=0.000)是胆囊结石的危险因素。结论年龄、体质量指数、高密度脂蛋白胆固醇是胆囊结石的危险因素,可通过控制体质量、降低血脂等措施来降低胆囊结石的发病率。
Objective To investigate the correlation between gallstone and metabolic syndrome. Method 2 716 cases of physical examination, of which 1 298 cases of gallstones were gallbladder stones group, 1 414 cases of non-gallbladder stones as control group, compared two groups of age, triglyceride, total cholesterol, systolic blood pressure, diastolic blood pressure, high Density lipoprotein cholesterol, low density lipoprotein cholesterol, body mass index, fasting blood glucose level Results The age of the gallstone group was (51.82 ± 13.73) years old, the triglyceride (1.97 ± 1.84) mmol / L, the total cholesterol [(4.95 ± 1.03) mmol / L], the systolic blood pressure (126.43 ± 18.81) mmHg , Diastolic blood pressure (78.76 ± 13.02) mmHg, low density lipoprotein cholesterol (2.94 ± 0.33) mmol / L, body mass index 26.06 ± 3.70 kg / m 2, fasting blood glucose 5.49 ± 1.71 mmol / L] were significantly higher than those in the control group (36.51 ± 13.26 years, 1.43 ± 1.40 mmol / L, 4.50 ± 1.00 mmol / L, 117.59 ± 16.02 mmHg, 73.90 ± 12.13, (2.36 ± 0.69) mmol / L, (23.46 ± 3.65) kg / m ~ 2, (5.14 ± 0.96) mmol / L] and high density lipoprotein cholesterol level [(1.24 ± 0.33) mmol / L] Multivariate logistic regression analysis showed that age (OR = 1.078, 95% CI: 1.070-1.086, P = 0.000), and body mass index increased in the control group [(1.37 ± 0.33) mmol / L] (OR = 2.166, 95% CI: 1.786-2.626, P = 0.000). The reduction of high density lipoprotein cholesterol (OR = 2.045, 95% CI: 1.499-2.791, P = 0.000) was a risk factor for gallstone disease. Conclusion Age, body mass index and high density lipoprotein cholesterol are the risk factors of gallstone. The incidence of gallstones can be reduced by controlling body weight and lowering blood lipids.