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目的探讨谷胱甘肽与川芎嗪两种药物联合治疗糖尿病周围神经病变的疗效。方法回顾性分析2005年2月至2007年8月固始县人民医院收治的126例谷胱甘肽与川芎嗪两种药物联合治疗的粮尿病神经病变患者的临床资料。治疗组给予谷胱甘肽和川芎嗪两种药物联合静脉滴注时间4周,对照组给予维生素B1肌注腺者辅配B12口服时间4周。结果两组临床疗效和治疗前后神经传导速度比较,治疗组与对照组治疗后均较治疗前提高,但治疗组提高更明显,差异有统计学意义。结论谷胱甘肽与川芎嗪两种药物联合治疗糖尿病周围神经病变的疗效确切,值得临床推广应用。
Objective To investigate the efficacy of combination of glutathione and ligustrazine in the treatment of diabetic peripheral neuropathy. Methods The clinical data of 126 patients with diabetic neuropathy who were treated with glutathione and ligustrazine were retrospectively analyzed from February 2005 to August 2007 in Gushi County People’s Hospital. The treatment group was given glutathione and ligustrazine two drugs combined intravenous infusion time of 4 weeks, the control group given vitamin B1 intramuscular gland supplements with B12 orally for 4 weeks. Results The clinical curative effect and nerve conduction velocity before and after treatment in both groups were significantly higher than those before treatment after treatment in treatment group and control group, but the treatment group improved more obviously with significant difference. Conclusion Glutathione and tetramethylpyrazine two drugs combined treatment of diabetic peripheral neuropathy curative effect is worthy of clinical promotion and application.