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多环芳烃(PAHs)是一类广泛存在于环境中的持久性有机化学污染物。研究表明,PAHs不仅能引起消化道和呼吸道刺激效应,长期暴露还会对哺乳动物产生致畸、致癌和致突变危害。PAHs在人体内主要以葡萄糖苷酸结合的形式存在,酶解后尿中羟基PAHs(OH-PAHs)作为主要的生物标志物可以综合评价人体多途径接触PAHs的内暴露水平。该文对近年来尿中OH-PAHs的不同前处理技术(水解、萃取净化)和检测方法(液相色谱-荧光检测法、气相色谱-质谱法、液相色谱-质谱联用法)进行综述,并对未来发展趋势进行展望。
Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic chemical pollutants that are widely present in the environment. Studies have shown that PAHs can not only cause gastrointestinal and respiratory irritation, but also give long-term mammalian teratogenic, carcinogenic and mutagenic effects. PAHs are mainly in the form of glucuronide binding in human body. Hydroxy PAHs (OH-PAHs) in urine can be used as the main biomarkers to evaluate the internal exposure of PAHs through multi-pathways. This review summarizes the different pretreatment techniques (hydrolysis, extraction and purification) and detection methods (liquid chromatography-fluorescence detection, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry) of OH-PAHs in urine in recent years. And look forward to the future development trend.