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目的探讨急性失血性贫血兔模型不同脑区磁敏感加权成像(SWI)信号值的变化。方法对10例新西兰大白兔急性失血性贫血模型行MRI扫描,测量SWI图像上双侧额叶皮层,额叶白质、颞叶皮层及丘脑核团的信号强度,并通过半定量方式评价脑灰白质对比度及静脉结构现象的情况。结果大白兔放血前大脑额叶皮层基础SWI信号值高于额叶白质,有统计学差异(F=117.04,P=0.01);经过连续放血后,兔的额叶皮层、颞叶皮层及丘脑灰质的SWI信号值均低于放血前基础SWI信号值,有统计学差异(F=8.10,P=0.01;F=7.67,P=0.01;F=6.72,P=0.02)。在半定量分析中,急性失血性贫血的大白兔在连续放血后其脑灰白质对比度及静脉结构的显示均优于放血前基础图像。结论 MRI SWI能反映急性失血性贫血的状态下,大脑皮质、灰质核团及白质不同的病理生理改变。
Objective To investigate the change of signal value of magnetic susceptibility weighted imaging (SWI) in different brain regions in acute hemorrhagic anemia rabbit model. Methods MRI scan of 10 New Zealand white rabbits with acute hemorrhagic anemia was performed to measure the signal intensity of bilateral frontal cortex, frontal white matter, temporal cortex and thalamic nuclei on SWI images. The gray matter Contrast and venous structure phenomenon. Results The basal SWI signal of the prefrontal cortex in pre-bleed rabbits was significantly higher than that in the frontal lobe (F = 117.04, P = 0.01). After continuous exsanguination, the prefrontal cortex, temporal cortex and thalamic gray matter (F = 8.10, P = 0.01; F = 7.67, P = 0.01; F = 6.72, P = 0.02), the SWI signal values were lower than the baseline SWI signal values before bloodletting. In semi-quantitative analysis, acute hemorrhagic anemia in white blood cells after continuous bleedings showed gray matter contrast and vein structure were better than pre-bleeding basic images. Conclusion MRI SWI can reflect the different pathophysiological changes of cerebral cortex, gray matter nucleus and white matter in acute hemorrhagic anemia.