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目的：本文的研究为临床用药和配制替硝唑（ＴＮＺ）外用药选择适宜药物浓度和促进剂浓度提供依据。方法：观察ＴＮＺ对小白鼠离体皮肤的透皮吸收，比较不同药物浓度的透皮吸收量及月桂氮酮（Ａｚｏｎｅ）不同浓度的促渗作用。结果：０．２％，０．４％，１．０％ＴＮＺ，１２ｈ透皮吸收量分别为１．４１，２．８２，７．１２ｍｇ·（５０ｍｌ）－１，渗透系数分别为１２．９８×１０－６，１３．６８×１０－６，１３．７７×１０－６。促渗剂Ａｚｏｎｅ含量在５％以下时，ＴＮＺ透皮吸收百分率随着Ａｚｏｎｅ浓度的提高而增加；当Ａｚｏｎｅ含量达８％时，透皮吸收率反而下降。结论：ＴＮＺ可透过离体小白鼠皮肤，提高药物浓度可增加药物的透皮吸收量。促渗剂Ａｚｏｎｅ用量以２％～５％为最佳
OBJECTIVE: This study provides the basis for selecting suitable drug concentration and promoting agent concentration for clinical use and topical tinidazole (TNZ) preparation. Methods: To observe the transdermal absorption of TNZ in isolated rat skin and compare the transdermal absorption of different concentrations of drug and the promoting effect of different concentrations of Azone. Results: The transdermal absorbances of 0.2%, 0.4%, 1.0% TNZ and 12h were 1.41, 2.82 and 7.12 mg · (50 ml) -1, respectively. The permeation coefficients were 12.98 × 10 -6, 13.68 × 10 -6, and 13.77 × 10 -6. When Azone content is below 5%, the transdermal absorption of TNZ increases with the increase of Azone concentration. When Azone content reaches 8%, transdermal absorption decreases. Conclusion: TNZ can penetrate the skin of isolated mice to increase the drug concentration and increase the transdermal absorption of the drug. Penetration enhancer Azone dosage of 2% to 5% is the best