论文部分内容阅读
目的:探讨健康体检人群血清25羟维生素D [25-（OH）D]水平和超敏C反应蛋白（hs-CRP）的关系。方法:以合肥市某单位746名健康体检人员为研究对象，其中男性489人，占65.5%，年龄为（47.2±15.6）岁。通过问卷调查方法收集人口统计学和疾病信息等，并测定血清25-（（OH））D和hs-CRP。将受检者按照25-（OH）D水平分为3组：非缺乏组（≥50 nmol/L）、缺乏组（25~<50 nmol/L）、严重缺乏组（<25 nmol/L）。将hs-CRP按75%百分位数分为正常组和高值组。25-（OH）D和hs-CRP的关联性采用多因素Logistic回归分析。结果:在维生素D严重缺乏组、缺乏组和非缺乏组中hs-CRP高值发生率分别为29.8%、26.4%和17.0%，差异具有统计学意义（χ2=6.471，n P<0.05）；Logistic回归分析显示，25-（OH）D缺乏组和严重缺乏组hs-CRP高值的发生率均高于25-（OH）D非缺乏组，n OR值（95n %CI）分别为1.851（1.122～3.053）和2.369（1.227～4.573），差异具有统计学意义（n P<0.05）。n 结论:血清25羟维生素D缺乏是成人hs-CRP高值的危险因素，对维生素D缺乏人群的营养干预可能有利于降低机体炎症水平。“,”Objective:To explore the association between serum 25-hydroxyvitamin D [25-(OH)D] and high-sensitivity C reactive protein (hs-CRP) levels in health check-ups population.Methods:A total of 746 patients who underwent health check-ups at an enterprise unit in Hefei city were selected as the study subjects with an average age of (47.2±15.6) years and 489 males, accounting for 65.5%. Demographical and disease information was collected through questionnaires. Serum 25-(OH)D and hs-CRP levels were measured. The subjects were divided into three groups according to the 25-(OH)D level: non-deficient group (≥50 nmol/L), deficient group (25 nmol/L to 49.9 nmol/L), severely deficient group (<25 nmol/L). C-reactive protein was divided into normal group and high value group by 75% percentile. Multivariate logistic regression was used to analyze the relationship between 25-(OH)D and hs-CRP levels.Results:The proportions of high CRP levels in the severely deficient, deficient, and non-deficient groups were 29.8%, 26.4%, and 17.0%, respectively, and the difference was statistically significant (χ2=6.471，n P<0.05). Logistic regression analysis showed that, compared with the non-deficient group of 25-(OH)D, the odds ratios values (95% n CI) of the high values of hs-CRP in the deficient group and the severely deficient group of 25-(OH)D were 1.851(1.122 to 3.053) and 2.369(1.227 to 4.573), respectively.n Conclusions:Serum 25-(OH)D level is a risk factor for hs-CRP in adults. Nutritional intervention in vitamin D deficient population may be beneficial to reduce the level of inflammation.