1病例报告患者女,78岁。既往无高血压病、糖尿病等病史,患帕金森病5年,服用多巴丝肼片,第1周服用半片,每天1次,以后每隔1周增加半片,达到3片(每次1片,每天3次)后症状明显改善,维持该用量5年。近期,患者夜间常出现震颤、痉挛等症状,考虑是出现了复方多巴制剂“开-关”现象。遂于晚上加服半片多巴丝肼,患者出现夜间不能坐立、头晕等症状,平卧时稍好转。 A case report patient female, 78 years old. Previously no history of hypertension, diabetes and other diseases, Parkinson’s disease for 5 years, taking basal hydrazine tablets, the first week of taking half a tablet, once daily, after every 1 week to increase half a tablet, up to 3 tablets , 3 times a day) symptoms improved significantly to maintain the amount of 5 years. Recently, patients often appear tremor during the night, spasms and other symptoms, consider the emergence of compound dopa preparations “on-off ” phenomenon. Then in the evening to take half the dose of doppler hydrazide, the patient can not stand at night, dizziness and other symptoms, supine slightly improved.