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药物性牙龈增生在临床上比较常见，是由某些药物引起的牙龈增生和体积增大，牙龈边缘和牙龈乳头增生为主要临床表现，不仅对患者的发音功能、咀嚼功能以及吞咽功能产生严重影响，同时给患者的生活也带来极大的痛苦，使患者产生心理障碍。目前对于药物性牙龈增生的发病机制尚无定论，仍需进行进一步的研究。该文就胶原合成与降解失衡机制、炎症机制、上皮细胞的增值和凋亡机制等方面作一综述。“,”Drug-induced gingival hyperplasia is more common in clinic.It is caused by some drugs.Gingival margin and gingival papilla hyperplasia are the main clinical manifestations.It not only has a serious impact on the voice function, chewing function and swallowing function of patients, but also brings great pain to patients′ life and mental function.At present, the pathogenesis of drug-induced gingival hyperplasia is still uncertain, and further research is needed.In this paper, the imbalance mechanism of collagen synthesis and degradation, the mechanism of inflammation, the mechanism of epithelial cell proliferation and apoptosis were reviewed.