我国最早的医方《五十二病方》,约成书于公元前3世纪末的战国时代,书中已出现了丸剂的名称。约成书于战国时代的《黄帝内经》也有“四乌贼骨一藘茹丸”(藘茹即茜草)的记载。公元前187年《史记》太仓公传中载有“半夏丸”之名。汉代名医张仲景(公元142～219年)应用蜂蜜、糖、淀粉及动物胶汁为丸药的赋形剂。梁代名医陶弘景(公元452～536年)提出丸剂应用理论:“疾有宜服丸者,宜服散……”。《千金方》(唐代)对炼蜜方法作了科学规定,并增用动物汁(牛胆汁等)、鸡蛋白、苦酒(醋)作赋形剂。以后又有应用鹅脂(晋代《肘后方》)、药汁(唐代《外台秘要》)、糯米糊(宋代《鸡峰普济方》)、神粬糊(宋代《济生方》)、汤浸蒸饼(元代《脾胃论》)等作赋形 China’s earliest medical party, the “Five-Two Diseases,” was written in the Warring States period at the end of the third century BC. The name of the pill has appeared in the book. The book “The Yellow Emperor Neijing” written in the book of the Warring States period also contains the record of “Four Squid bones and a ruthenium pill.” In the 187th year BC, the “Historical Records” Taicang public biography contained the name “Tang Xia Pill.” In the Han Dynasty, Zhang Zhongjing (142-219 AD) used honey, sugar, starch and animal glue as excipients for pills. Liang Yiming Tao Hongjing (AD 452-536 AD) proposed the theory of pill application: “Sick and suitable pills should be taken, should serve loose...”. The “Qian Jin Fang” (Tang Dynasty) made a scientific stipulation on the method of refining honey, and added animal juice (bile, etc.), egg white, and bitter wine (vinegar) as excipients. Later, there are applications of goose butter (Jing Dynasty “elbow rear”), concoction (Tai Dynasty “outside Taiwan secret”), glutinous rice paste (Song Dynasty “Chifeng Puji Fang”), God paste (Song Dynasty "Ji Sheng Fang ”), soup dip steamed cake (Yuan Dynasty “spleen and stomach”) and other shaping