抗菌药物后效应是指细菌与抗菌药物短暂接触,当药物浓度下降低于最低抑菌浓度(MIC)或消除后,细菌生长仍受到抑制的效应。抗菌药物后效应已成为评价抗菌药物药效学的重要参数。随着抗菌药物后效应研究的不断深入,人们逐渐认识到,许多抗菌药物的抗菌活性与药物的峰浓度密切相关,即呈明显的剂量依赖性,其体内浓度不必始终维持在 Antibacterial effect refers to the bacteria and antibacterial drugs after a brief exposure, when the drug concentration decreased below the minimum inhibitory concentration (MIC) or eliminated, the bacterial growth is still inhibited. Antibacterial effect has become an important parameter to evaluate the pharmacodynamics of antimicrobial agents. With the deepening of the research on the post-antimicrobial effect, people gradually realized that the antibacterial activity of many antibacterials is closely related to the peak concentration of the drug, ie, in a dose-dependent manner. The in vivo concentration does not need to be always maintained at