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[目的]观察益肺合剂联合西药治疗气阴耗伤耐多药肺结核疗效。[方法]使用随机平行对照方法,将60例住院及门诊患者按就诊顺序号抽签方法简单随机分为两组。对照组30例,阿米卡星0.5g/次(或卡那霉素0.75/次、卷曲霉素0.75/次)1次/d,肌注,左氧氟沙星0.75/次,1次/d,口服;对氨基水杨酸钠4.0/次,2次/d,口服(或环丝氨酸0.25/次,2次/d,口服);吡嗪酰胺0.8/次,2次/d,口服;丙硫异烟胺0.25/次,2次/d,口服。治疗组30例益肺合剂(黄芪、北沙参、麦冬、桑叶、百部、黄精、百合、生晒参、黄芩、丹参、野荞麦、阿胶等)水煎300mL,150mL/次,2次/d,口服;西药治疗同对照组。连续治疗2周为1疗程。观测临床症状、咳嗽、咳痰、体温、盗汗、皮肤微潮、不良反应。连续治疗2疗程(4周),判定疗效。[结果]治疗组痊显效8例,有效19例,无效5例,总有效率84.83%;对照组显效3例,有效12例,无效13例,总有效率53.57%;治疗组疗效优于对照组(P<0.01)。症状积分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]益肺合剂联合西药治疗气阴耗伤耐多药肺结核,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yifei Mixture combined with western medicine on gas-wasting and multi-drug resistant tuberculosis. [Methods] Using randomized parallel control method, 60 inpatients and outpatients were randomly divided into two groups randomly according to the lot number of visiting doctor. 30 patients in the control group, amikacin 0.5g / time (or kanamycin 0.75 / time, capreomycin 0.75 / time) once / d, intramuscular injection, levofloxacin 0.75 / time, once / d, Sodium paracetamol 4.0 / time, 2 times / d, oral (or serine 0.25 / times, 2 times / d, oral); pyrazinamide 0.8 / times, 2 times / d, oral; Amine 0.25 / time, 2 times / d, orally. The treatment group 30 cases of Yifei mixture (Astragalus, Radix notoginseng, Ophiopogon japonicus, mulberry leaves, a hundred, Polygonatum, Lily, raw sunburn, skullcap, Salvia, wild buckwheat, donkey-hide gelatin, etc.) decoction 300mL, 150mL / Times / d, oral; Western medicine treatment with the control group. Continuous treatment for 2 weeks for a course of treatment. Observation of clinical symptoms, cough, sputum, body temperature, night sweats, skin micro-tidal, adverse reactions. Continuous treatment of 2 courses (4 weeks), determine the efficacy. [Results] In the treatment group, 8 cases were effective, 19 cases were effective, 5 cases were ineffective and the total effective rate was 84.83%. In the control group, 3 cases were markedly effective, 12 cases were effective and 13 cases were ineffective. The total effective rate was 53.57% Group (P <0.01). Symptom score improved in both groups (P <0.01), and the treatment group improved better than the control group (P <0.01). [Conclusion] Yifei Mixture combined with western medicine can cure gas-toxin-resistant and multi-drug resistant tuberculosis, with satisfactory curative effect and no serious adverse reactions. It is worth to be popularized.