早在20多年前就有人认识到巨噬细胞(Mφ)对肿瘤细胞的细胞毒作用,但Mφ在蠕虫感染中的免疫功能直到最近才引起人们的重视。由于蠕虫(例如血吸虫、丝虫和钩虫等)是危害人体的主要寄生虫,因此,了解机体对蠕虫感染的免疫防御机制具有实际的临床意义。通过一系列的实验研究表明,Mφ在抗蠕虫感染时具有明显的免疫效应。一般认为Mφ对多细胞的寄生虫可通过多种途径产生细胞毒作用:包括自然杀伤活动和在补体 As early as 20 years ago, it was recognized that the macrophage (Mφ) cytotoxic effect on tumor cells, but Mφ immune function in worm infection until recently attracted much attention. Because worms such as schistosomiasis, filariasis and hookworm are the major parasites that endanger the human body, it is of practical clinical significance to understand the immune defense mechanism of the body against helminth infections. Through a series of experimental studies, Mφ showed a significant immune effect against worms. Mφ is generally believed that multi-cellular parasites can produce cytotoxic effects in a variety of ways: including natural killer activity and in complement