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目的研究对氧磷酶2与白三烯受体在儿童支气管哮喘中表达的相关性及临床生物学意义,为儿童哮喘发病机制提供分子病理学研究基础。方法以正常儿童群体为对照采用双抗体夹心ELISA法比较对氧磷酶2与白三烯受体在儿童支气管哮喘不同亚组及缓解组中的差异。结果对氧磷酶2与白三烯受体的表达在正常儿童、哮喘急性发作患儿中存在明显差异。哮喘患儿根据其症状严重程度分组,轻症组与重症组差异有统计学意义(P<0.01或<0.05),且其表达水平与症状存在正相关关系,r值分别为0.81和0.73(P<0.05)。结论对氧磷酶2与白三烯受体可作为独立风险预测因子判定儿童哮喘的演进和转归。
Objective To study the correlation between the expression of paraoxonase 2 and leukotriene receptors in children with bronchial asthma and its clinical significance and to provide a molecular basis for the pathogenesis of asthma in children. Methods To compare the differences of paraoxonase 2 and leukotriene receptors in different subgroups and remission groups of children with bronchial asthma by double antibody sandwich ELISA in normal children. Results The expression of paraoxonase 2 and leukotriene receptors were significantly different in normal children and children with acute asthma attacks. Children with asthma grouped according to the severity of their symptoms, the difference between mild and severe group was statistically significant (P <0.01 or <0.05), and its expression level and the presence of a positive correlation between symptoms, r values were 0.81 and 0.73 (P <0.05). Conclusion Paraoxonase 2 and leukotriene receptors may be used as independent risk predictors to determine the evolution and outcome of childhood asthma.