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目的:调查广东籍汉族气虚质鼻咽癌患者的HLA(人类白细胞抗原)易感性。方法:应用聚合酶链反应/序列特异性引物(PCR-SSP)方法对34例广东籍汉族气虚质鼻咽癌患者及正常对照组30例进行HLA-A、HLA-B及DR B1基因分型。结果:广东籍汉族气虚质鼻咽癌患者的HLA-A*02、HLA-B*15、HLA-DR B1*03基因位点的频率高于正常对照组。结论:HLA-A*02、HLA-B*15、HLA-DR B1*03可能是广东籍汉族气虚质鼻咽癌患者的易感性基因。
Objective: To investigate the susceptibility of HLA (human leukocyte antigen) in patients with nasopharyngeal carcinoma of the Han nationality with qi deficiency in Han nationality in Guangdong province. Methods: Polymerase chain reaction / sequence specific primers (PCR-SSP) were used to detect the HLA-A, HLA-B and DR B1 genotypes in 34 Han Chinese patients with QHD and 30 normal controls . Results: The frequencies of HLA-A * 02, HLA-B * 15 and HLA-DR B1 * 03 loci in Han-Qi-Han-NPC patients in Guangdong were higher than those in normal controls. Conclusion: HLA-A * 02, HLA-B * 15 and HLA-DR B1 * 03 may be the susceptibility genes of patients with nasopharyngeal carcinoma of qi deficiency in Han nationality in Guangdong province.