论文部分内容阅读
1 对象和方法1.1 对象自1992年4月始,经内镜检查、病理证实的胃窦部重度萎缩性胃炎伴肠化生的男性患者46例。以2:1随机分为2组,治疗组与对照组的平均年龄分别为42.8岁和40.5岁,病程为3.4和3.1年,两组比较无显著差异(P>0.05)。有空腹时上腹部胀满闷堵、嗳气、呃逆、烧灼,无反酸。①内镜检查:胃窦粘膜皱襞消失、变薄,血管显露,白相,灰白色结节扁平状隆起。定点定位钳取4处粘膜活检。②病理改变:粘膜层明显变薄,腺体减少>2/3且被肠腺所代替,排列紊乱。1.2 方法治疗组用蝮蛇抗栓酶0.5 IU,而对照组用维生素 C2g,均加入5%葡萄糖250ml 中静滴,1次/d,同时均加服多潘立酮10mg,谷维素30mg,VB_6 10 mg。3次/d,15d 为1个疗程,共2个疗程。
1 objects and methods 1.1 objects since the beginning of April 1992, by endoscopy, pathologically confirmed gastric atrophic gastritis with intestinal metaplasia in 46 cases of male patients. The patients were randomly divided into 2 groups at 2: 1. The mean age of treatment group and control group were 42.8 years and 40.5 years respectively. The course of disease was 3.4 and 3.1 years. There was no significant difference between the two groups (P> 0.05). Fasting abdominal fullness stuffy block, belching, hiccups, burning, no acid. ① endoscopy: gastric mucosal folds disappear, thinning, blood vessels revealed, white, white nodules flat uplift. Fixed-point positioning pliers to take 4 mucosal biopsy. ② pathological changes: mucosal obvious thinning, gland reduction> 2/3 and replaced by gut gland, arranged disorder. 1.2 Methods The treatment group with vitex antithrombin 0.5 IU, while the control group with vitamin C2g, were added 5% glucose 250ml intravenous infusion, 1 / d, while taking service domperidone 10mg, oryzanol 30mg, VB_6 10mg. 3 times / d, 15d for a course of treatment, a total of 2 courses.