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B7-H3是新近发现的共刺激分子B7家族的一个新成员,在T细胞介导的免疫反应中发挥重要的调节作用。B7-H3蛋白在正常组织、细胞中不表达或极低表达,却高表达于多种实体肿瘤组织,如前列腺癌、肾透明细胞癌、非小细胞肺癌等,并与肿瘤的进展、患者的生存及预后密切相关。本文就常见实体肿瘤中B7-H3的表达情况及临床指导意义作一综述。
B7-H3 is a newly discovered member of the B7 family of co-stimulatory molecules that plays an important regulatory role in T cell-mediated immune responses. B7-H3 protein in normal tissues, cells are not expressed or very low expression, but high expression in a variety of solid tumor tissues, such as prostate cancer, renal clear cell carcinoma, non-small cell lung cancer, and tumor progression, the patient’s Survival and prognosis are closely related. This article reviews the expression of B7-H3 in solid tumors and its clinical significance.