AIM:It is known that toxoplasmosis rarely leads to variousliver pathologies,most common of which is granulomatosehepatitis in patients having normal immune systems.Patientswho have cirrhosis of the liver are subject to a variety ofcellular as well as humoral immunity disorders.Therefore,itmay be considered that toxoplasmosis can cause morefrequent and more severe diseases in patients with cirrhosisand is capable of changing the course of the disease.Theaim of this study was to investigate the frequency oftoxoplasmosis in patients with cirrhosis.METHODS:Serum samples were taken from 108 patientswith cirrhosis under observation in the Hepatology Polyclinicof the Gastroenterology Clinic,and a control group madeup of 50 healthy blood donors.IFAT and ELISA methodswere used to investigate the IgG and IgM antibodies,whichhad developed from these sera.RESULTS:Toxoplasma IgG and IgN antibody positivity wasfound in 74 (68.5%) of the 108 cirrhotic patients and 24(48%) of the 50 people in the control group.The differencebetween them was significant (P<0.05).CONCLUSION:In conclusion,it was found that thetoxopiasma sero-prevalence in the cirrhotic patients in thisstudy was higher.Cirrhotic patients are likely to form atoxoplasma risk group.More detailed studies are neededon this subject. AIM: It is known that toxoplasmosis rarely leads to various pathology, most common of which is granulomatosehepatitis in patients having normal immune systems. Patients with cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity disorders. Wherefore, itmay be considered ( that toxoplasmosis can cause morefrequent and more severe diseases in patients with cirrhosisand is capable of changing the course of the disease.Theaim of this study was to investigate the frequency oftoxoplasmosis in patients with cirrhosis. METHODS: Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic, and a control group made up of 50 healthy blood donors. IFAT and ELISA methods used to investigate the IgG and IgM antibodies, which developed since these sera. RESULTS: Toxoplasma IgG and IgN antibody positivity was found in 74 ( 68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the cont rol group. The difference between them was significant (P <0.05) .CONCLUSION: In conclusion, it was found that the toxopiasma sero-prevalence in the cirrhotic patients in this study was higher. Cirrhotic patients are likely to form atoxoplasma risk group. More detailed studies are neededon this subject.