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目的研究血型糖蛋白Ａ（ＧＰＡ，ｇｌｙｃｏｐｈｏｒｉｎＡｌｏｃｕｓ）突变分析用作新的辐射生物剂量计。方法结合流式细胞分析和单克隆抗体标记技术，检测红细胞糖蛋白的变异。结果随访全国１０例放射源事故受照者，４人为ＭＮ杂合体，生物剂量在１４６～２９Ｇｙ，１人ＭＮ弱阳性。ＧＰＡＮＯ变异率与剂量线性回归曲线有显著意义，曲线斜率４１５３×１０－６／Ｇｙ，而ＮＮ没有显著意义。结论ＧＰＡ变异率剂量效应曲线二次线性拟合比一次线性好。二次线性重建远期辐射剂量高于一次模型，用原爆、切尔诺贝利、戈亚尼亚事故参数回顾剂量多偏高。
Objective To study the mutation of GPA (glycophorinAlocus) for use as a new biological radiation dosimeter. Methods Combined with flow cytometry and monoclonal antibody labeling, the variation of erythrocyte glycoprotein was detected. Results The follow-up of 10 cases of radioactive incident victims in the country, 4 were MN heterozygotes, biological dose of 1 46 ~ 2 9Gy, 1 weak MN. GPANO mutation rate and dose linear regression curve is significant, the slope of the curve 41 53 × 10-6 / Gy, and NN is not significant. Conclusion GPA mutation rate dose-response curve quadratic linear fit is better than linear. The long-term radiation dose of quadratic linear reconstruction was higher than that of the first model. The parameters of primary explosion, Chernobyl and Goiania were reviewed and the doses were high.