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目的 :探讨胎膜早破孕妇直肠内应用米索前列醇促宫颈成熟和引产的临床效果及可行性。方法 :选择足月妊娠、胎膜早破、宫颈 Bishop评分≤ 6分的孕妇共 85例 ,分成 组 44人 ; 组 41人 ,分别口服和直肠内应用米索前列醇 5 0μg,每 3h一次。观察用药到临产的时间、产程进展、分娩结局及副反应的发生等情况。结果 :首次用药到规律宫缩的时间 组明显短于 组 (P<0 .0 1)。宫缩过强致胎儿窘迫的例数 组明显多于 组。其余指标两组无显著差异。结论 :与口服用药相比 ,直肠内应用米索前列醇具有药效稳定、持续时间长、副反应少的优越性。对胎膜早破的孕妇可用其代替阴道局部用药。
Objective: To investigate the clinical effect and feasibility of using misoprostol to induce cervical ripening and induction of labor in premature rupture of membranes in pregnant women. Methods: A total of 85 pregnant women with full-term pregnancy, premature rupture of membranes, and cervical Bishop score ≤ 6 were divided into 44 groups and 41 were treated with oral misoprostol and 50 μg of omeprazole every 3 hours. Observed medication to labor time, labor progress, delivery outcome and the occurrence of side effects and so on. Results: The first time medication to regular contractions time was significantly shorter than the group (P <0.01). The cases of fetal distress caused by contractions were significantly more than the group. The remaining indicators of two groups no significant difference. Conclusion: Compared with oral administration, the application of misoprostol in rectum has the advantages of stable efficacy, long duration and few side effects. Pregnant women with premature rupture of membranes can be used instead of vaginal topical medication.