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目的:探讨莫西沙星诱导尖端扭转型室速(TDP)的规律及特点,为临床合理用药提供参考。方法:检索近10年有关莫西沙星致TDP的病例报道,共5例,并进行分析。结果:男性2例,女性3例,平均年龄(81±7)岁;5位患者均存在器质性心脏病;口服给药较静脉给药发病时间延迟;发病时心电图QTc间期均值为(567±35)ms;停药后心电图QTc间期恢复至入院时基线水平的时间为(18±15)h;发病时血钾、镁、钙水平均正常。结论:临床医师、药师应重视莫西沙星诱导TDP的不良反应。
Objective: To investigate the rules and characteristics of moxifloxacin induced torsades de pointes (TDP), and to provide a reference for clinical rational drug use. Methods: The case reports of Moxifloxacin-induced TDP in the recent 10 years were retrieved and analyzed in 5 cases. Results: There were 2 males and 3 females with an average age of (81 ± 7) years. All 5 patients had organic heart disease. The onset time of oral administration was longer than that of intravenous injection. The mean QTc interval of electrocardiogram was ( 567 ± 35) ms. The QTc interval after electrocardiogram withdrawal was (18 ± 15) h, and the serum potassium, magnesium and calcium levels were normal. Conclusion: Clinicians and pharmacists should pay attention to the adverse reaction induced by moxifloxacin in TDP.