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目的探讨甲硝唑阴道泡腾片联合结合雌激素软膏倍美力治疗老年性阴道炎的临床疗效。方法将本院2009年收治的老年性阴道炎患者90例,随机分为对照组(A组)与治疗组(B组),每组45例,A组给予甲硝唑阴道泡腾片,B组应用甲硝唑栓阴道泡腾片联合适量倍美力软膏。连续20d后,评价两组临床效果,了解临床症状及体征改善进展,检测血清促卵泡生成素(FSH)以及血清雌二醇(E2)差异,统计药物使用后的副作用。结果 20d治疗后,B组的总有效率(有效率显效率及显效率)明显高于A组(P<0.05),治疗组的临床症状和体征轻于A组(P<0.05);B组E2低于A组,FSH高于A组,检测结果差异有统计学意义(P<0.05),两组药物副作用发生率差异无统计学意义(P<0.05)。结论老年性萎缩性阴道炎用甲硝唑阴道泡腾片加倍美力软膏治疗效果确切,临床症状和体征明显减轻,副作用少,值得借鉴。
Objective To investigate the clinical efficacy of metronidazole vaginal effervescent tablets in combination with estrogen ointment for the treatment of senile vaginitis. Methods 90 cases of senile vaginitis admitted in our hospital in 2009 were randomly divided into control group (group A) and treatment group (group B), 45 cases in each group. Group A received metronidazole vaginal effervescent tablets, B Group application of metronidazole suppository vaginal effervescent tablets combined with the amount of times the United States and ointment. After 20 consecutive days, the clinical effects of two groups were evaluated to see the improvement of clinical symptoms and signs, the differences of serum follicle-stimulating hormone (FSH) and serum estradiol (E2) were detected, and the side effects after drug use were counted. Results After 20 days of treatment, the total effective rate (effective rate and markedly effective rate) in group B was significantly higher than that in group A (P <0.05), and the clinical symptoms and signs in treatment group were lighter than those in group A (P <0.05) E2 was lower than that of group A, FSH was higher than that of group A, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of side effects between the two groups (P <0.05). Conclusion The treatment of senile atrophic vaginitis with metronidazole vaginal effervescent tablets and double the US force ointment treatment effect is clear, clinical symptoms and signs significantly reduced, fewer side effects, it is worth learning from.